您现在的位置:食品科学网>杂志>下载

Ketogenic diets and Alzheimer’s disease

阅读:
2017-06-15 来源:食品科学网
责任编辑:食品科学
0

  作者:Klaus W. Lange a,∗, Katharina M. Lange b, Ewelina Makulska-Gertruda a, Yukiko Nakamuraa,

  关键词:Alzheimer’s disease; Ketone bodies; Ketogenic diet; Therapy

  内容:

Abstract
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by decline in cognitive functions and associated with the neuropathological hallmarks of amyloid -peptide plaques and neurofibrillary tangles. Cerebral glucose uptake and metabolism deteriorate in AD and this hypometabolism precedes the onset of clinical signs in AD. The early decline in brain glucose metabolism in AD has become a potential target for therapeutic intervention. This has led to investigations assessing the supplementation of the normal glucose supply with ketone bodies which are produced by the body during glucose deprivation and can be metabolized by the brain when glucose utilization is impaired. The present review provides a synopsis of preclinical studies and clinical trials assessing the efficacy of ketogenic diets in the treatment of AD. Both the direct administration of ketone bodies and the use of high-fat, low-carbohydrate ketogenic diets have been shown to be efficacious in animal models of AD and clinical trials with AD patients. The mechanism underlying the efficacy of ketogenic diets remains unclear, but some evidence points to the normalization of aberrant energy metabolism. At present there is only limited evidence of the usefulness of ketogenic diets in AD. However, this dietary approach seems to be promising and deserves further clinical investigations.

相关阅读

  • 来源:新京报  |  2016-05-19
    阅读:386

    中粮1元“贱卖”君顶酒庄或因巨债流拍

    4月15日,北京产权交易中心挂出“中粮旗下中国食品拟1元底价拍卖中粮君顶酒庄55%股权”的消息,引起行业一片哗然。1元拍卖的背后实则附有昂贵的“条件”,中标者需承担君顶酒庄所欠中粮3.92亿元的债务,而其实际对外欠账总额高达5亿多元。

  • 来源:新京报  |  2016-05-19
    阅读:386

    央视记者随机买8份草莓 均检出可致癌农药残留

    京华时报讯(记者常鑫),前天,央视财经频道《是真的吗》节目播出一组有关草莓的报道,称该栏目组记者随机在北京购买的8份草莓均检测出含有百菌清和乙草胺两种农药。

  • 来源:新京报  |  2016-05-19
    阅读:386

    麦当劳奶昔退役 业内分析恐因销量下挫

    曾在麦当劳中国餐厅服役近24年的奶昔昨日正式谢幕。虽然麦当劳中国方面称此举属正常产品调整,不过在业内看来,销量的不断下滑或才是此次奶昔下架的真正原因。

微博

食品科学服务号

食品科学订阅号

食品书店

食品科学

定价:25.00¥
会员价:20.00¥

合作伙伴