领学术科研之先，创食品科技之新
—— 中国食品杂志社
Fuzhuan brick-tea (FZT) has long been consumed for its supposed weight loss and lipid-lowering benefits. In this study, we show that the regulation of fat storage in Caenorhabditis elegans from a water extract of FZT was affected by cholesterol levels. We found that FZT significantly decreased fat storage under normal cholesterol levels or in a cholesterol-free diet, while lipid accumulation was increased for a high cholesterol diet. Moreover, this mechanism may involve the conserved sterol regulatory element-binding protein (SREBP)/ mediator-15 (MDT-15) signaling pathway and the nuclear hormone receptor NHR-80. In addition, lipid synthesis-related genes inhibited by FZT were partially affected by a cholesterol-free diet. Thus, our findings suggested that the potential lipid-lowering effects of FZT may depend on the cholesterol level, which may help to improve the consumption of FZT.
电话: 010-87293157
地址: 北京市丰台区洋桥70号
版权所有 @ 2023 中国食品杂志社 京公网安备11010602060050号 京ICP备14033398号-2
