领学术科研之先，创食品科技之新
—— 中国食品杂志社
This study is to investigate the potential of wolfberry water extracts for the treatment of Alzheimer’s
disease (AD) and the relationship between their anti-AD property and the geographic locations in China.
Total extracts of all wolfberry samples showed the potent to decrease self-induced Aβ1-42 aggregation and
Cu2+-induced Aβ1-42 aggregation and the antioxidant capacity as well as the bioactivity for binding biometal.
A transgenic drosophila model assay revealed that TE of S1 and S6 (S1-TE and S6-TE) at 100 g/mL
demonstrated the potent rescue effect on memory loss compared to the positive control memantine
at 20 g/mL. Further study also revealed the polysaccharide extracts could contribute to their anti-AD
property, and the anti-AD activity conspicuously depends on growing environment. Wolfberry samples
S1 and S6 showed much more potent anti-AD property. Meanwhile this study demonstrated that the
Chinese commonly consumed wolfberry in boiling water might have the beneficial function to prevent
AD pathology.
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