领学术科研之先，创食品科技之新
—— 中国食品杂志社
Multi-drug (or multi-element) combinations are often prescribed in the practice of clinical medicine
and as foods for special medical purposes. The main motivations for these combinations are that most
diseases contain multiple related targets and an appropriate combination can maximize benefits while
minimizing adverse reactions. As such, it is especially important to derive mathematical models for their
quantitative calculation. In this paper, we introduce mathematical rules for the synergistic, additive, and
antagonistic effects of multi-drug combinations developed in our laboratory.Wehave established a “onebelt,
one-line” model and provide examples of the quantitative calculation of the synergistic, additive,
and antagonistic effects of a combination of multiple components. We also explain how to scientifically
and precisely determine the intensity of these synergies, additions and antagonisms, as well as their
corresponding dose ranges, thereby laying a solid theoretical foundation for market listing combinatorial
drugs and foods for special medical purposes.
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