领学术科研之先，创食品科技之新
—— 中国食品杂志社
To establish experimental high uric acid model in C. elegans. Hypoxanthine, adenine, xanthine, and uric
acid were used to treat C. elegans and then hyperuricemic C. elegans was evaluated by allopurinol. Hyperuricemic
C. elegans were obtained after normal worms were treated by xanthine (0.25 mg/mL, 18 h).
For hyperuricemic worms, there was a statistically significant increase in the uric acid level (p < 0.001)
and a lower drug damage (p > 0.05). Moreover, the model was proved to keep a high uric acid level for
up to 12 h. After given allopurinol (0.25 mg/mL, 12 h), the uric acid of hyperuricemic C. elegans had a
significant reduction by 15%. Furthermore, xanthine oxidase activity in hyperuricemic C. elegans showed
a statistically significant increase (p < 0.001), which resulted in a raised uric acid content. A high uric acid
model with low drug damage and high efficiency and stability was established in C. elegans after simply
xanthine treatment.
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