The renoprotective effects of Chinese chive water and ethanol extracts (CCWE and CCEE) on adenineinduced
chronic renal failure (CRF) mice were evaluated in this study. Results showed that the renal
pathological damages and the enhancement of serum creatinine and blood urea nitrogen of CRF mice
could be significantly alleviated by the treatment of CCWE, but not CCEE. When the concentration of
CCWE reached 200 mg/kg/day, the area of renal pathological damage was decreased to the 48.1% of model
group, and the levels of serum creatinine and blood urea nitrogen were decreased to the 87.7% and 83.9%
of model group, respectively. Meanwhile, it could be found that renal oxidative stress and inflammation
of CRF mice were remarkably inhibited by CCWE. These results indicated CCWE could improve the kidney
function of CRF mice via enhancing antioxidant ability and inhibiting inflammation, and was the main
renoprotective fraction of Chinese chive.
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