This study aimed to explore the application status of natural products in gastric ulcer research and explore the research hotspots and future research directions. CiteSpace was used to conduct metrological and visual analysis on the number of articles published in the core set of Web of Science database about natural medicines therapy for gastric ulcer, including co-cited journals, co-cited authors, co-cited literatures and keywords. From 1953 to 2021, the number of articles published on natural medicines therapy for gastric ulcer was 1 373, the total number of articles had increased rapidly in recent years. China and the United States were the driving force in this field, and the main research institution was Chinese Univ. Hong Kong. Most of the publications are in the journal Gastroenterology. “peptic ulcer”, “Helicobacter pylori”, “infection”, “duodenal ulcer”, “disease”, “gastric ulcer”, “peptic ulcer disease”, “gastric cancer”, and “prevalence” were the research frontiers in recent years. This study was the first to conduct literature metrology visualization analysis on the research status and hot spots and development trend of natural medicines against gastric ulcer, in order to provide reference for follow-up researchers to quickly understand the research focus of natural medicines against gastric ulcer and literature retrieval. In addition, this paper also put forward suggestions and prospected for the future development of this field, which will help researchers to open up new directions for future research in this field.