Intake of marine phospholipids can ameliorate the gut microbiota dysbiosis, thereby improving the metabolic disturbance of the host. It is unclear whether consuming marine phospholipids affects the gut microbiota community structure in a normal-diet host. The aim of this research was to compare the gut microbiota community structure between normal-diet mice consuming and not consuming large yellow croaker roe phospholipids (LYCRPLs) by 16S rRNA amplicon sequencing technology. Results indicated that LYCRPLs could regulate the relative abundance of some certain bacteria of normal-diet mice, i.e., increasing the abundance of some beneficial genera including Lachnospiraceae_NK4A136_group and Lactobacillus, and decreasing harmful bacteria such as GCA-900066575 and Romboutsia. Simultaneously, intake of LYCRPLs was predicted to reduce the bacterial biosynthesis of carbohydrate and lipids. This research revealed the regulation of LYCRPLs on the gut microbiota community structure in normal-diet mice, and provides a valuable reference for LYCRPLs as a functional ingredient in the food industry.
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