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Vitamin b6, a vital micronutrient acquired through dietary intake, plays a crucial role in numerous enzymatic reactions within the human body. Despite its significance, deficiencies in vitamin b6 remain prevalent and are linked to a spectrum of chronic and acute diseases. this review explored the intricate relationships between vitamin b6 metabolism and various diseases, focusing on cancer, diabetes, cardiovascular conditions, neurodegenerative disorders, and CoViD-19-related complications. We highlighted the mechanistic roles of pyridoxal 5’-phosphate, the active form of vitamin b6, in processes such as inflammation modulation, homocysteine regulation, and oxidative stress mitigation. by synthesizing recent advances in both clinical and preclinical studies, this paper underscores the therapeutic potential of vitamin b6 while advocating for personalized nutritional interventions tailored to individual health profiles. our findings aim to inform future research, foster targeted disease prevention strategies, and optimize the safe use of vitamin b6 as part of a balanced nutritional approach.
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