内容: Postmenopausal estrogen deficiency predisposes women to atherosclerosis and cardiovascular pathologies. Edible dock protein-derived enzymatic hydrolysates (EDP), rich in ultra-short peptides, exhibit potential vascular protective properties, yet their efficacy in postmenopausal settings remains undefined. Utilizing an ovariectomized (OVX) rat model, we demonstrate that EDP, while not restoring estrogen/progesterone levels, significantly counteracted OVX-induced hyperlipidemia (reduced total cholesterol/low-density lipoprotein cholesterol, LDL-C) and rescued acetylcholine-mediated vasodilation in high-dose treatment (H-EDP). Single-cell transcriptomics of thoracoabdominal aortas revealed OVX-driven immune dysregulation: monocyte/macrophage expansion, T-cell depletion, disrupted Treg/Th17 equilibrium, and pro-inflammatory T cell receptor (TCR)/nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) activation. EDP rebalanced lymphoid populations (Treg/Th17 restoration), suppressed pro-inflammatory mediators, and enhanced anti-inflammatory transforming growth factor-β (TGF-β) signaling. In myeloid compartments, EDP attenuated neutrophilia and monocytosis while inhibiting atherogenic metabolism. Endothelial analysis highlighted EDP-enhanced lymphangiogenesis and immune-endothelial crosstalk via CXC chemokine ligand 12 (CXCL12)/CXC chemokine receptor 4 (CXCR4) axis. Smooth muscle cells exhibited EDP-mediated recovery of contractile SMC-Des populations, and modulation of leukocyte recruitment through vascular cell adhesion molecule-1 (VCAM1)-Integrin α4β1 interactions. Fibroblast profiling showed EDP-induced expansion of Fibro-Barx1 subsets, restoring ECM homeostasis via Jag1-Notch2 pathways. Critically, EDP achieved these effects independent of estrogen restoration, establishing it as a hormone-independent therapeutic strategy to mitigate vascular dysfunction and immune-metabolic dysregulation in estrogen-deficient states.

内容: Artemisia argyi H. Lév. & Vaniot, commonly known as Chinese mugwort, is a wild vegetable with a long history of dietary use in China, and Qiai is its cultivated variety. However, it has not yet been included in China food catalog. Based on traditional folk edible processing methods, we developed A. argyi tender leaf powder (AATLP) to evaluate its safety. Here, the food safety of processed AATLP was assessed through acute toxicity, genotoxicity, repeated dose 90-day oral toxicity, and teratogenicity tests. AATLP components and human consumption were analyzed and surveyed, respectively. Results showed that the oral half lethal dose of AATLP was greater than 7.5 g/kg body weight (BW), indicating that it is practically non-toxic. Genotoxicity results (Ames, micronucleus, chromosome aberration) were negative. The results of 90-day oral toxicity test showed the no-observed-adverse-effect level (NOAEL) of 8.0 g/kg BW, without toxicological changes. The teratogenicity test indicated a NOAEL of 6.45 g/kg BW. Human consumption survey revealed no adverse effects. In conclusion, the findings provide toxicological and human survey evidence to confirm that A. argyi tender leaves can be used in food preparation for human consumption.

内容: The authors were contacted after publication to request an erratum of the paper “Oleanonic acid inhibits glioma growth by inactivating STAT3 via upregulating SIRT6 in nude mice”. In the original publication of our paper, “Oleanonic acid inhibits glioma growth by inactivating STAT3 via upregulating SIRT6 in nude mice,” which appeared in the journal of Food Science and Human Wellness, Vol. 14, Issue 5, Article number 9250347 (DOI: 10.26599/FSHW.2024.9250347), the authors have identified several errors that require correction. The authors apologize for any inconvenience.